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Regenerative mechanisms often require reemployment of pathwa
2024-04-19
Regenerative mechanisms often require reemployment of pathways used during development in the embryonic and postnatal periods (Waschek, 2002). PACAP has diverse neurodevelopmental and growth factor-like effects (Botia et al., 2007; Vaudry et al., 2009; Waschek, 2002; Watanabe et al., 2016) and it is
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Another interesting interaction concerns NMDA preconditionin
2024-04-19
Another interesting interaction concerns NMDA preconditioning to protect against glutamate neurotoxicity. It has been shown that an A1R antagonist prevented neuroprotection evoked by NMDA preconditioning against glutamate-induced cellular damage in cerebellar granule cells. In this study, the functi
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Genetic observations from these studies suggest
2024-04-19
Genetic observations from these studies suggest that GMF regulates Arp2/3 complex and melatonin receptor agonists dynamics in vivo13, 14. Budding yeast Gmf1 localizes to cortical actin patches, sites of endocytosis assembled by Arp2/3 13, 14. Furthermore, deletion of GMF1 exacerbates the growth def
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Finasteride has been shown to be a mechanism
2024-04-19
Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a
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Double immunofluorescence staining of Gas and Axl with
2024-04-19
Double immunofluorescence staining of Gas6 and Axl with neuronal specific nuclear protein (NeuN), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (Iba-1), demonstrated that Gas6 and Axl are expressed by neurons, astrocytes and microglia/macrophages (Fig. 2). In
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Based on these findings the
2024-04-19
Based on these findings, the time point for manipulating autophagy may also determine its role, whereby autophagy induction performed before ischemia could play a protective role but have an opposite effect once ischemia/reperfusion has occurred. This hypothesis is further supported by the protectiv
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At first the APC is a kDa
2024-04-19
At first, the APC is a 310kDa protein divided into three domains such as N-terminal, central core and C-terminal domain [102], plays a major role to regulate the Wnt signaling pathway in human cancer by translating β-catenin from the Phosphatase Inhibitor Cocktail (2 Tubes, 100X) to the nucleus [10
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These anatomical studies were followed by the first function
2024-04-19
These anatomical studies were followed by the first functional MRI studies of auditory processing in songbirds that were performed in starlings (Van Meir et al., 2005; De Groof et al., 2017; De Groof et al., 2013b) and in zebra finches (Boumans et al., 2008a; Boumans et al., 2007; Boumans et al., 20
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br Experimental procedures br Results br
2024-04-19
Experimental procedures Results Discussion Although previous studies have indicated that astrocyte aromatase plays a role in nociceptive processes (O'Brien et al., 2015, Smeester et al., 2016), the mechanisms responsible for the regulation of aromatase and its involvement in nociception rem
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br Experimental and simulation section br
2024-04-19
Experimental and simulation section Acknowledgments Financial support for this work was provided by the National Natural Science Foundation of China (No. 81101688). We would like to thank NC State University High Performance Computing Center for providing us computing resources, and Dr. Lihui
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Autophagy is a self protecting cellular catabolic pathway th
2024-04-19
Autophagy is a self-protecting cellular catabolic pathway that degrades and recycles cytoplasmic contents for the maintenance of cellular homeostasis (Shao et al., 2016b). Macrophage autophagy plays an essential role in atherosclerosis by safeguarding TPEN against oxidative stress, reducing apoptosi
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Later on Wayner Burton Ingold Barclay
2024-04-19
Later on, Wayner, Burton, Ingold, Barclay, and Locke (1987) modified the method by using lipid to examine the ability of an antioxidant pd 1 receptor protect against lipid peroxidation generated by azo-compound. It was later improved using β-phycoerythrin (β-PE) as a fluorescent probe, and the abili
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Unfortunately results of serum plasma AC
2024-04-19
Unfortunately, results of serum/plasma AC assessment after food antioxidant intake are rather controversial: although some papers reported an increase of AC after food antioxidant intake (Khan et al., 2015, Torabian et al., 2009), unexpectedly, in a lot of long-term intervention studies (days, weeks
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Bran is a byproduct of flour
2024-04-19
Bran is a byproduct of flour milling, typically utilized as a valuable component of animal feeds. Because of its attractive technological and health-promoting properties, it Propidium iodide has also been increasingly used in food manufacturing as a source of dietary fiber. Indeed, with the growing
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The fluorescence in a fluorescent antibiotic can
2024-04-19
The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not