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br Material and methods br
2018-11-08
Material and methods Results Discussion The current study is the first report of the dynamic expression of ATF3 by ependymal spinal stem cells, as this protein was localized to the cytoplasm when such cells were quiescent, but was found in their nucleus when cells became activated. This pro
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Because SAPK mediates hyperosmolar stress induced Hand
2018-11-08
Because SAPK mediates hyperosmolar stress-induced Hand1 and Hand1-dependent PL1 (Awonuga et al., 2011), we tested whether stress-induced lineage choice during hypoxia was SAPK-dependent. Since hyperosmolar stress induces the first lineage but not later lineages from TSC (Liu et al., 2009), and SAPK
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Here we report that Dll counteracts the proliferation
2018-11-08
Here we report that Dll4 counteracts the proliferation of murine HPCs such as Lin−Sca+c-Kit+ (LSK) cells, by keeping a higher fraction of cells in the G0 state. This event was correlated with a downmodulation of some key atipamezole genes transcription such as D-CYCLINS. Furthermore, Dll4 limits th
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The identification of progenitor populations in the adult he
2018-11-08
The identification of progenitor populations in the adult heart adds increased complexity to heart development, and raises many interesting questions – for example, are fetal or adult CPCs remnants of earlier embryonic progenitors, have they migrated in from other sources, or have they arisen de nov
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br Materials and methods br
2018-11-08
Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by ll-37 that were not multipotent, based upon their differentiation capacity as determined
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br Materials and methods br Results and discussion
2018-11-08
Materials and methods Results and discussion Acknowledgments Introduction Reprogramming rejuvenates aged somatic cells back into the pluripotent state (Takahashi et al., 2007; Takahashi and Yamanaka, 2006). The developmental plasticity of induced pluripotent stem cells (iPSC) demonstrate
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A plausible interesting observation coming out
2018-11-08
A plausible interesting observation coming out from this study is that DNA methylation imprint at H19 DMR may be more sensitive to loss of TET proteins in undifferentiated ES serine protease inhibitors than they are in differentiated cells, whereas DNA methylation imprint at Peg1 DMR may be more pro
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Recent methods of reprogramming human fibroblasts to iNSCs e
2018-11-08
Recent methods of reprogramming human fibroblasts to iNSCs employed genome-integrating lentiviral or retroviral vectors (Kumar et al., 2012; Ring et al., 2012), which may produce insertional mutations and residual or reactivation of transgenes. We used oriP/EBNA-1 episomal vectors to deliver reprogr
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In order to assess the
2018-11-08
In order to assess the cellular proliferation potential colony forming efficiency was determined. As we decided to apply a low suction vacuum pressure in order to minimize potential discomfort during bone marrow harvest under local anesthesia in the control individuals the achieved mean cell yields
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br Acknowledgements br Resource table br Resource details
2018-11-08
Acknowledgements Resource table Resource details To generate the Saudi KACST induced Pluripotent Stem Cell line No 1 (SKiPSc1) cell line, four reprogramming Yamanaka factors (Oct3/4, Sox2, c-Myc, and Klf4) (Takahashi et al., 2007; Yu et al., 2007) were delivered to HNFFs by Sendai viral inf
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br Materials and methods br Acknowledgments We
2018-11-08
Materials and methods Acknowledgments We would like to thank Dr. Saran Karumbayaram for providing guidance in the culture and expansion of the primate fibroblasts. We would also like to thank Steven Dowdy for depositing the T7-VEE-OKS-iG plasmid (Addgene). This project was funded by NIH grant
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silybin Induction of EndMT results from integration of multi
2018-11-08
Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa
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To examine the functional role of IGFBP
2018-11-08
To examine the functional role of IGFBP-2 and -3 we conducted the experiments described in Fig. 4 where the effects of IGFBP-2 and -3 were examined either uncomplexed or complexed with IGF1. The data indicated that IGF1 stimulated ALP activity in DPCs in a dose dependant manner and although there we
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It was recently shown that hPSCs can
2018-11-08
It was recently shown that hPSCs can be expanded as cell-only dnmt in serum-free suspension culture irrespective of matrix supplementation (Amit et al., 2011; Olmer et al., 2010; Singh et al., 2010), which is mandatory for conventional surface-attached propagation of hPSCs. In contrast to matrix-at
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Studies from other glandular tissues like mammary gland reve
2018-11-08
Studies from other glandular tissues, like mammary gland, revealed CD24hi/CD29lo- (Shackleton et al., 2006) expressing NVP-TNKS656 as potential stem cells. In mice, we reported that intraglandular transplantation of primary-sphere-derived CD24+/CD29+ cells could ameliorate radiation-induced hyposali
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